Departments of Chemistry & Molecular Biosciences

Lynn Hancock

Associate Professor
Director, Beckman Scholarship Program
Primary office:
8047 Haworth

Selected Publications

Representative Publications
  • Varahan S, Iyer VS, Moore WT, Hancock LE#. 2013. Eep confers lysozyme resistance to Enterococcus faecalis via the activation of the extracytoplasmic function sigma factor, SigV. J. Bacteriol. 195(14): 3125-34. Epub 2013 May 3.  
  • Teixeira N, Varahan S, Gorman MJ, Palmer KL, Zaidman-Remy A, Yokohata R, Nakayama J, Hancock LE, Jacinto A, Gilmore MS, Lopes MFS. 2013.  Drosophila host model reveals new Enterococcus faecalis quorum-sensing associated virulence factors.  PLoS One May 29;8(5):e64
  • Teixeira N, Santos S, Marujo P, Yokohata R, Iyer VS, Nakayama J, Hancock LE, Serror P, Lopes MFS#. 2012. The incongruent gelatinase genotype and phenotype in Enterococcus faecalis are due to shutting off the ability to respond to the gelatinase biosynthesis-activating pheromone (GBAP) quorum-sensing signal. Microbiol. 158(Pt 2):519-28. Epub 2011 Nov 24.
  • Iyer VS, Hancock LE#. 2012. Deletion of Sigma54 (rpoN) alters the rate of autolysis and biofilm formation in Enterococcus faecalis. J. Bacteriol. 194(2):368-75. Epub 2011 Nov 11
  • Srivastava M, Mallard C, Barke T, Hancock LE, Self WT. 2011. A selenium-dependent xanthine dehydrogenase triggers biofilm proliferation in Enterococcus faecalis through oxidant production.  J. Bacteriol. 193(7):1643-52. Epub 2011 Jan 21.
  • Thurlow LR, Thomas VC, Narayanan S, Olson S, Fleming SD, Hancock LE#. 2010. Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis. Infect Immun. 78(11):4936-43. Epub 2010 Aug 16. 
  • Manson JM, Hancock LE, and MS Gilmore#. 2010. Mechanism of chromosomal transfer of Enterococcus faecalis pathogenicity island, capsule, antimicrobial-resistance and other traits. Proc Natl Acad Sci U S A.  107(27):12269-74. Epub 2010 Jun 21.  
  • Guiton PS, Hung CS, Hancock LE, Caparon MG, Hultgren SJ#. 2010. Enterococcal biofilm formation and virulence in an optimized murine model of foreign body-associated urinary tract infections. Infect. Immun. 78(10):4166-75. Epub 2010 Aug 9.
  • Macovei L, Ghosh A, Thomas VC, Hancock LE, Mahmood S, and Zurek L.# 2009. Enterococcus faecalis with the gelatinase phenotype regulated by the fsr operon and with biofilm-forming capacity are common in the agricultural environment. Environ. Microbiol. 11(6): 1540–1547. 
  • Thomas VC, Hiromasa Y, Harms N, Thurlow L, Tomich J, Hancock LE#. 2009. A fratricidal mechanism is responsible for eDNA release and biofilm development of Enterococcus faecalis. Mol. Microbiol. 72(4):1022-36. This paper was featured in the Research Highlights section of Nature Reviews Microbiology June 2009 vol. 7 no. 6, pg. 403.
  • Thurlow LR, Thomas VC, Hancock LE#. 2009. Capsular polysaccharide production in Enterococcus faecalis and the contribution of CpsF to capsule serospecificity.  J. Bacteriol. 191(20):6203-10. Epub 2009 Aug 14.
  • Thomas VC, Hancock LE#. 2009.  Suicide and fratricide in bacterial biofilms. Int J Artif Organs. 32(9):537-442.
  • Thurlow LR, Thomas VC, Fleming SD, Hancock LE#. 2009. Enterococcus faecalis capsular polysaccharide serotypes C and D and their contributions to host innate immune evasion. Infect Immun. 77(12):5551-7 Epub 2009 Oct 5.
  • Thomas VC, Thurlow LR, Boyle D, Hancock LE#. 2008. Regulation of autolysis-dependent eDNA release by Enterococcus faecalis extracellular proteases influences biofilm development. J. Bacteriol. 2008 Aug;190(16):5690-8. Epub 2008 Jun 13.

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